Zymurgy

Zymurgy is a SpeedIF game, which means that it was written in a short period of time to fit a certain prompt. In this case, the prompt was: "Write a game in which the PC is fighting for his religion, which should involve the worship of cheese and/or alcohol. Try to include pasta, Decepticons or Windows XP." Roger Carbol decided to set the game inside a brewery, indeed, inside a vat of beer that is fermenting. The protagonist is a yeast cell trying to do everything it can to please its god, the Brewmeister, and the holy law, the Bavarian Reinheitsgebot.

It's certainly unique, and the implementation is solid. Of course, as a SpeedIF the game is very short and over almost before it has begun. Finding the winning solution also contains a non-trivial element of luck.

(I played this game as part of an IFDB Spelunking expedition where I try to play through ten random games.)

The PC is a yeast cell.
Who practices a religion.
And saves the Universe.
And the game takes place inside a large bottle.
And UP and DOWN are the only directions.
And the game's title is one of the very last words in English dictionaries.
What's not to like?