Axolotl is a fantastic sci fi Twine game with a large map, big inventory, multiple NPC's with menu-driven conversation, and so on.
You play a researcher of alien salamanders on the moon. The corporation you are working for is breathing down your neck, and things start to go wrong. A mystery develops, a surprisingly deep mystery, that I found extremely satisfying.
Also, this is a surprisingly fresh Twine game, as it avoids many of the overused Twine tropes: world-weariness, body horror, and psychological metaphor are all avoided for a better sci fi story.
One of the best Twine games ever.